Here we provide as much information as we can on AC-262, a relatively unknown SARM which some have compared to Ostarine in terms of its effects.
AC-262 is a non-steroidal selective androgen receptor modulator (SARM) that was created and introduced to the market by ACADIA Pharmaceuticals in San Diego, California.
What is AC-262 (Accadrine)?: The Lowdown on This Relatively Unknown SARM
Initial research on this SARM started in 2007 with animal studies and, as yet, there have been no human trials or studies done on it since. Likewise, there are few anecdotal reports about it (we could find only a handful of accounts on Reddit).
Before we go into more detail about AC-262, first we’ll give you a quick run-through of what SARMs are and how they’re used. If you want to read about SARMs in detail, we recommend consulting our one-stop primer on them, which features as part of our Ultimate Series on SARMs.
What Are SARMs? How Are They Used?
A sixty-day SARMs transformation
“SARMS” stands for “selective androgen receptor modulators.” These compounds work similarly to steroids by binding to the body’s androgen (male hormone) receptors and recoding DNA to become more efficient — or “tissue selective — at packing on muscle.
Unlike anabolic steroids, which bind to androgen receptors in many tissues all over the body, individual SARMs selectively bind to androgen receptors in certain tissues, but not in others.
Although originally developed as “steroidal SARMS” for a viable cure for osteoporosis, cancer, and other diseases in the 1940’s by Ligand Pharmaceuticals, “non-steroidal” SARMS were pioneered in the 90s by GTx Inc giving us the SARMS we use today.
SARMs have presented themselves as an attractive alternative to androgenic anabolic steroids (AAS) in recent years because they boast fewer side effects and because they occupy a legal grey area. SARMs are legal in most territories, with some notable exceptions such as Australia, where a prescription is necessary for them.
It’s worth noting though, that, because of their anabolic and performance-enhancing properties, most SARMs are a prohibited substance and are listed as an S1 Anabolic Agent on WADA’s prohibited list.
As SARMs are more “tissue-selective” while boasting far fewer androgenic side effects — hair loss, acne, prostate enlargement, clitoral enlargement, unwanted hair growth, etc. —they have begun to become more popular than AAS in many parts of the world.
Bodybuilders and powerlifters alike run SARMs and even stack them with steroids to yield their desired results. This is because SARMs can yield keepable muscle and strength gains without drastic hormonal shifts.
SARMs also tend to be consumed in liquid form, another advantage if you don’t like the idea of having to inject yourself to take an anabolic compound.
SARMs cycles typically last between 2-3 months depending on the compound or stack (mixture of compounds taken), but this may vary according to several factors such as stack, user experience and dosage.
AC-262 Review: What is AC-262536 used for?
How Strong Is AC-262?
Our trusted provider SWISS CHEMS describes AC-262 as “a great alternative to… Ostarine.”
“AC-262536 exerted up to 66% of the anabolic benefits of Testosterone, while simultaneously only exerting 27% as much Androgenic activity.
From this we can conclude that AC-262536 has an anabolic:androgenic rating/ratio of 2.45:1
For the record, none of the SARMs that have been developed are entirely selective for anabolic effects in muscle and bone without producing some trace androgenic effects in tissues.
The most notable being the prostate gland, which we can use as a gauge to assess how androgenic a SARM is based on its’ effect on the prostate gland to some extent.
There are several SARMs that have anabolic:androgenic ratios of 3:1 and up though, and those are fairly typical.
The highest ratio among the mainstream SARMs we are aware of is currently RAD-140 with an anabolic:androgenic ratio of 90:1.
This doesn’t mean that RAD-140 will significantly outperform AC-262536 in all aspects, but it does shed some light on what we can expect as we increase the dosage of AC-262536 in our research (the higher the dose, the more androgenic side effects we can expect to start cropping up, as opposed to RAD-140 where you can expect significantly more anabolic activity than androgenic activity each time the dosage increases).”
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As we’ve already stated, there isn’t a great deal of information on AC-262 at the present. The rodent studies went as high as 30mg/kg, but without human studies it’s difficult to translate this into an equivalent effective human dose.
More Plates More Dates suggests that dosages between 10 and 30mg are effective, which are typical amounts for SARMs.
Do I Need a PCT if I Take AC-262?
Because SARMs mimic the role of naturally produced androgens in the human body, they will suppress levels of these hormones; however, the individual response will vary and some compounds, such as Ostarine, are generally considered to be less “suppressive” than others. As a result, some SARMs cycles might require post-cycle therapy (PCT) shortly after consumption or even liver protection such as NAC to combat hepatotoxicity from certain oral compounds.
If you want to know more about PCT, read our guide here.