Ligandrol, otherwise known as VK5211 or LGD-4033, is a selective androgen receptor modulator (SARM) that was initially developed as a means to combat muscle wastage and osteoporosis.

As with Ostarine, it has been shown in clinical trials since its discovery by Ligand Pharmaceuticals to help significantly in the increase of lean muscle mass and strength.  

Ligandrol molecule
The Ligandrol molecule (C14H12F6N2O)

Again, as we cautioned in the Ostarine article, you must understand that ligandrol has specific uses that will suit some people and purposes more than others. If you put it to the right uses, you will see very positive results, with fewer of the side effects associated with the use of performance-enhancing substances like steroids. 

You must, however, be in no doubt of the potential risks and side effects, which we will discuss below.

The lowdown

Ligandrol is another anabolic SARM, like ostarine, and is generally sought out and used by the same groups: bodybuilders, strength athletes (powerlifters, Olympic lifters, strongmen), practitioners of contact sports, martial artists and gymbros. The benefits of ligandrol are more or less the same as those of ostarine.

  • Reduced body fat
  • Increased lean muscle mass (even in a caloric deficit) and therefore strength
  • Increased energy levels
  • Increased bone strength 

The anecdotal evidence seems to be that ligandrol may even help you put on more mass than ostarine, but some of that extra mass may be of a lesser quality, i.e. may be water weight due to mineral retention.

Ostarine appears to have better fat loss properties than ligandrol and can be used effectively to gain muscle during a caloric deficit.

Ligandrol may also have more potent side effects than ostarine; although, in both cases, the side effects are mild compared to steroids, unless you use the SARMs at much higher dosages than normal, and even then you won’t encounter problems like an enlarged prostate or gynecomastia.

Ligandrol, as a SARM with performance-enhancing effects, is listed as an S1 Anabolic Agent on WADA’s prohibited list.

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