You may have heard of the original SARM LGD-4033 or “Ligandrol” — but what about LGD-3303, the new and updated version of the OG SARM?
Lifters and athletes alike seeking to perfect their craft may turn to performance enhancing drugs such as SARMs to get the most out of their training.
But what is the nascent hype surrounding LGD-3303 all about?
Like with most SARMs, this updated version of Ligandrol is developed for medical purposes with patients of muscle-wasting diseases, such as cancer, in mind.
As SARMs are tissue-selective — meaning that they don’t cause organ enlargement — SARMs are a safer alternative to anabolic steroids when developed for certain medical conditions.
What is LGD-3303?
Also known as VK5211 and Anabolicum, LGD-3303 is a Selective Androgen Receptor Modulator (SARM) created by Ligand Pharmaceutals similar in nature to LGD-4033.
According to Ligand Pharmaceuticals:
“LGD-3303 is a potent and highly selective androgen receptor full agonist in skeletal muscle, a classic target tissue for androgen action. By comparison, in the prostate and sebaceous glands, the compound is a weak partial agonist. The sparing of these non-target tissues by effective, pharmacologic doses of LGD-3303 provides a novel and potentially safer treatment for osteoporosis.”
They previously said: ” Ligand tested the effect of LGD-3303 on bone density and strength in a three-month study using daily oral doses in ovariectomized, osteopenic rats, a well established model of post-menopausal osteoporosis.”
However, athletes and recreational weightlifters may choose to employ SARMs such as LGD-3303 to enhance their performance in the gym or within their discipline of choice.
How does LGD-3303 Compare With LGD-4033?
At first glance, LGD-3303 appears to be a revamped version of LGD-4033 with slightly dryer gains, a more limited side effect profile, and a shorter half-life of up to 6-12 hours. However, more research is needed to ascertain the side effects of this relatively unknown SARM.
According to the above graph, it is a partial agonist to the prostate and full-on agonist to muscles.
MPMD goes onto write:
“As you can see, at the 1 mg/kg/day dosage (the dosage roughly equivalent to the standard starting daily dosage for research in humans) the effect on prostate weight (proposed androgenic activity) was minimal relative to what prostate weight was when the research subject wasn’t using LGD-3303 at all.
“With this statistic, we can assume that the androgenic effects in the body are minimal at the effective dosage for muscle building purposes, thus making it a very promising SARM.
“LGD-3303 shares a very similar chemical structure to LGD-4033, which is a far more “mainstream” and popular SARM, notorious for its’ fantastic mass building properties relative to the other most commonly used SARMs.”
How it compares with LGD-4033:
- Dryer Gains
- Similar “Pop” to wetter compounds
- Helps preserve lean muscle tissue in caloric deficit
- Strength gains
- Shorter half-life
- Anecdotally more suppressive
How to Buy LGD-3303?
We are not medical professionals and do not condone or condemn the use of SARMs or other PEDs. Be sure to consult a trained professional before commencing a regimen that involves SARMs or other PEDs.
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