A study performed on mice claimed that the SARM RAD 140 might be safer for older men than testosterone replacement therapy (TRT).

Researchers at the University of Southern California, Los Angeles, concluded that RAD 140 may have a lower overall risk profile on patients undergoing TRT.

This is due to SARMs’ tissue selectiveness when binding to the androgen receptor, while testosterone is more indiscriminate as to which androgen receptors it binds to.

Testosterone can cause prostate enlargement and thus increase the risk of prostate cancer in older men undergoing TRT for a variety of reasons, namely Sarcopenia.

Read our master article on SARMs for more information.

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RAD 140 Safer than TRT?

SARMs in 2021
Jon Anthony from Masculine Development shows off his SARMs transformation

The study begins with: “The decline in testosterone levels in men during normal aging increases risks of dysfunction and disease in androgen-responsive tissues, including brain. The use of testosterone therapy has the potential to increase the risks for developing prostate cancer and or accelerating its progression. To overcome this limitation, novel compounds termed “selective androgen receptor modulators” (SARMs) have been developed that lack significant androgen action in prostate but exert agonist effects in select androgen-responsive tissues.”

We have written extensively on the effects of falling testosterone levels and its socially catastrophic effects.


SARMs have shown promise as a viable alternative for TRT. Although MK-677 (Ibutamoren) is not a SARM, per se, some TRT clinics have begun administering it to their patients.

The study continues:

One significant limitation of androgen therapy is the potential for increased risk of developing prostate cancer and or accelerated growth of existing prostate tumors. To overcome this problem, new classes of synthetic testosterone-like compounds, called “selective androgen receptor modulators” (SARMs), have been developed (3031). SARMs are ligands for AR that exert limited effects in prostate and other reproductive tissues but have potent androgenic actions in muscle and bone (3233).

Although SARMs such as 7α-methyl-19-nortestosterone undergo enzymatic aromatization to yield metabolites that bind to ER (34), most of the currently available SARMs are poor substrates for aromatase and interact specifically with AR (35). The possible utility of SARMs for therapeutic use in AD and other neural disorders has only recently begun to be investigated.

We advise you to consult your physician before undergoing a fitness regimen or before consuming SARMs or any performance enhancing drugs. We are not trained medical professionals and do not condemn or condone the use of SARMs.

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